Polycomb-dependent epigenetic landscape in adult T-cell leukemia

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Polycomb-dependent epigenetic landscape in adult T-cell leukemia.

Adult T-cell leukemia-lymphoma (ATL) shows global gene expression alterations that confer cellular characteristics and unfavorable prognosis. However, molecular mechanisms of the sustained expression changes are largely unknown, because there is no study addressing the relationship between landscapes of the gene expression and epigenetic modifications. Here, we analyzed ATL epigenome and integr...

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ژورنال

عنوان ژورنال: Blood

سال: 2016

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2015-08-662593